RT Journal Article
T1 Bioavailability and nervous tissue distribution of pyrethroid insecticide cyfluthrin in rats
A1 Rodríguez, José Luis
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 Martínez Larrañaga, María Rosa
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
AB Toxicokinetics of cyfluthrin after single oral [20 mg/kg body weight (bw)] and intravenous (IV) (3 mg/kg bw) doses were studied in rats. Serial blood samples were obtained after oral and IV administration. Brain tissue samples were also collected after oral administration. Cyfluthrin concentrations in plasma and brain tissues (hypothalamus, striatum, hippocampus and frontal cortex) were quantified using liquid chromatography tandem mass spectrometry (LC/MS). Cyfluthrin disposition was best described by the use of a two-compartment open model. When given orally, plasma kinetics showed an extensive oral absorption of cyfluthrin and a slow elimination. The area under the concentration-time curve [AUC (0–24h)] and maximal plasma concentration (Cmax) were 6.11 ± 1.06 mg h/L and 0.385 ± 0.051 μg/mL, respectively; β phase elimination half-life (T1/2β) was (17.15 ± 1.67 h). Oral bioavailability was found to be 71.60 ± 12.36%. After oral administration, cyfluthrin was widely distributed to brain tissues. AUC (0–24h) was significant higher in all tested brain tissues than in plasma. The largest discrepancy was found for hypothalamus. AUC (0–24h), Cmax and T1/2β in hypothalamus were 19.36 ± 2.56 mg h/L, 1.21 ± 0.11 μg/g and 22.73 ± 1.60 h, respectively. Assuming the identified toxicokinetics parameters, this study serves to better understand mammalian toxicity of pyrethroid cyfluthrin and to design further studies to characterize its neurotoxicity.
PB Elsevier
SN 0278-6915
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/97282
UL https://hdl.handle.net/20.500.14352/97282
LA eng
NO Rodríguez JL, Ares I, Martínez M, Martínez-Larrañaga MR, Anadón A, Martínez MA. Bioavailability and nervous tissue distribution of pyrethroid insecticide cyfluthrin in rats. Food Chem Toxicol. 2018 Aug;118:220-226. doi: 10.1016/j.fct.2018.05.012. Epub 2018 May 8. PMID: 29751079.
DS Docta Complutense
RD 30 dic 2025