RT Journal Article
T1 Noncooperative thermodynamics and kinetic models of ligand binding to polymers: Connecting McGhee-von Hippel model with the Tonks gas model
A1 García Villaluenga, Juan Pedro
A1 Vidal, Jules
A1 Cao García, Francisco Javier
AB Ligand binding to polymers modifies the physical and chemical properties of the polymers, leading to physical, chemical, and biological implications. McGhee and von Hippel obtained the equilibrium coverage as a function of the ligand affinity, through the computation of the possible binding sites for the ligand. Here, we complete this theory deriving the kinetic model for the ligand-binding dynamics and the associated equilibrium chemical potential, which turns out to be of the Tonks gas model type. At low coverage, the Tonks chemical potential becomes the Fermi chemical potential and even the ideal gas chemical potential. We also discuss kinetic models associated with these chemical potentials. These results clarify the kinetic models of ligand binding, their relations with the chemical potentials, and their range of validity. Our results highlight the inaccuracy of ideal and simplified kinetic approaches for medium and high coverages.
PB American Physical Society
SN 1539-3755
YR 2020
FD 2020-07-20
LK https://hdl.handle.net/20.500.14352/6521
UL https://hdl.handle.net/20.500.14352/6521
LA eng
NO ©2020 American Physical Society.
DS Docta Complutense
RD 2 may 2024