RT Journal Article
T1 Biomimetic camouflaged nanoparticles with selective cellular internalization and migration competences
A1 Jiménez Jiménez, Carla
A1 Moreno Borrallo, Almudena
A1 Dumontel, Bianca
A1 Manzano, Miguel
A1 Vallet Regí, María Dulce Nombre
AB In the last few years, nanotechnology has revolutionized the potential treatment of different diseases. However, the use of nanoparticles for drug delivery might be limited by their immune clearance, poor biocompatibility and systemic immunotoxicity. Hypotheses for overcoming rejection from the body and increasing their biocompatibility include coating nanoparticles with cell membranes. Additionally, source cell-specific targeting has been reported when coating nanoparticles with tumor cells membranes. Here we show that coating mesoporous silica nanoparticles with membranes derived from preosteoblastic cells could be employed to develop potential treatments of certain bone diseases. These nanoparticles were selected because of their well-established drug delivery features. On the other hand MC3T3-E1 cells were selected because of their systemic migration capabilities towards bone defects. The coating process was here optimized ensuring their drug loading and delivery features. More importantly, our results demonstrated how camouflaged nanocarriers presented cellular selectivity and migration capability towards the preosteoblastic source cells, which might constitute the inspiration for future bone disease treatments.
SN 17427061
YR 2022
FD 2022-12-05
LK https://hdl.handle.net/20.500.14352/72916
UL https://hdl.handle.net/20.500.14352/72916
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO European Research Council
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 30 jul 2024