RT Journal Article
T1 Pleuroperitoneal canal closure and the fetal adrenal gland
A1 Hayashi, Shogo
A1 Fukuzawa, Yoshitaka
A1 Rodríguez Vázquez, José Francisco
A1 Baik, Hwan Cho
A1 Verdugo López, Samuel
A1 Murakami, Gen
A1 Nakano, Takashi
AB Pleuroperitoneal canal (PP canal) closure is generally considered to result from an increase in the height, and subsequent fusion, of the bilateral pleuroperitoneal folds (PP folds). However, the folds develop in the area ventral to the adrenal, in contrast to the final position of the diaphragm, which extends to the dorsal side of the adrenal (the "retro-adrenal" diaphragm). We examined the semiserial histology of 20 human embryos and fetuses (crown-rump length 11-40 mm). We started observations of the canal at the stage through which the lung bud extends far caudally along the dorsal body wall to the level of the future adrenal, and the phrenic nerve has already reached the PP fold. Subsequently, the developing adrenal causes narrowing of the dorsocaudal parts of the canal, and provides the bilateral midsagittal recesses or "false" bottoms of the pleural cavity. However, at this stage, the PP fold mesenchymal cells are still restricted to the ventral side of the adrenal, especially along the liver and esophagus. Thereafter, in accordance with ascent of the lung, possibly due to anchoring of the liver to the adrenal, the PP fold mesenchymal cells seem to migrate laterally along the coelomic mesothelium covering some sheet-like loose mesenchymal tissue behind the adrenal. Final closure of the PP canal by lateral migration to provide the "retro-adrenal" diaphragm is a process quite different from the common dogma. It is likely that the sheet-like loose mesenchymal tissue becomes the caudal part of the pleural cavity through a process involving cell death.
PB Wiley
SN 1932-8486
YR 2011
FD 2011-04
LK https://hdl.handle.net/20.500.14352/97567
UL https://hdl.handle.net/20.500.14352/97567
LA eng
NO Hayashi S, Fukuzawa Y, Rodríguez-Vázquez JF, Cho BH, Verdugo-López S, Murakami G, Nakano T. Pleuroperitoneal canal closure and the fetal adrenal gland. Anatomical Record (Hoboken). 2011 Apr;294(4):633-44.
DS Docta Complutense
RD 16 abr 2025