RT Journal Article
T1 MDR Reversal by Deprenylated Tetracyclic and Hexacyclic Analogues of N-Acetylardeemin: Confirmation of the Ardeemin Pharmacophore
A1 Avendaño López, María Carmen
A1 Caballero, Esmeralda
A1 Mendez-Vidal, Cristina
A1 Quesada, Ana R. de
A1 Menéndez Ramos, José Carlos
AB The MDR chemosensitising activity of several analogues of the ardeemins, including five derivatives of the ABCD fragment, nine derivatives of the complete hexacyclic framework and one seco analogue lacking the B ring was studied. The results obtained confirm that the pharmacophoric moiety of the ardeemins as MDR reversers is located at their DEF fragment, and suggest that the epimer of the ardeemins at the alanine stereocenter should be more active than the natural stereoisomer.
PB Bentham Science Publishers
SN 1570-1808
YR 2006
FD 2006
LK https://hdl.handle.net/20.500.14352/133494
UL https://hdl.handle.net/20.500.14352/133494
LA eng
DS Docta Complutense
RD 17 mar 2026