RT Journal Article
T1 Trattamento con escitalopram e peso corporeo : dati preliminari
T2 Escitalopram treatment and weight changes : preliminary data
A1 Belli, Simone
A1 Pacciardi, Bruno
A1 Cotugno, B.
A1 Cargioli, C.
A1 Augusto, S.
A1 Di Fiorino, A.
A1 Mauri, M.
AB IntroductionWeight gain is a common problem during antidepressant treatment, an important factor contributing to noncompliance, and a key issue influencing obesity-related illnesses. Selective serotonin reuptake inhibitors (SSRIs) seem to differ in terms of their effects on body weight, but the available literature on this topic is sparse, contradictory and lacking of data about new generation SSRIs.MethodsThis work evaluated clinical improvement and weight changes during the first three months of escitalopram treatment in 34 outpatients affected with depression and comorbid anxiety, assessed in a naturalistic follow-up. Outcome measures were weight change and clinical improvement assessed with CGI.ResultsAfter the first three months of therapy, there was a slight decrease in average body weight compared to baseline. However, the weight loss at three months did not reach statistical significance. Response to treatment was demonstrated by a statistically significant reduction in CGI score.LimitationsBoth the small sample size and short follow-up times limit our results. Other variables such as depressive severity, atypical features and premorbid weight should be taken into account during further follow-up.ConclusionsOur preliminary data suggest that escitalopram may not be involved in weight gain, and confirm the efficacy of escitalopram treatment for depression with comorbid anxiety.
PB Società Italiana di Psicopatologia
SN 1592-1107
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/101195
UL https://hdl.handle.net/20.500.14352/101195
LA ita
DS Docta Complutense
RD 11 abr 2025