RT Journal Article
T1 Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients
A1 González Sánchez, Marta
A1 Pérez Martínez, David Andrés
A1 Villarejo Galende, Alberto
A1 Carro, Eva
AB Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. Thus, altered KYNA levels may suggest an inflammatory response. Very recently, significant increases in KYNA levels were reported in cerebrospinal fluid (CSF) from AD patients compared with normal controls. In this study, we assessed the accuracy of KYNA in CSF for the classification of patients with AD, cognitively healthy controls, and patients with a variety of other neurodegenerative diseases, including frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and progressive supranuclear palsy (PSP). Averaged KYNA concentration in CSF was higher in patients with AD when compared with healthy subjects and with all the other differentially diagnosed groups. There were no significant differences in KYNA levels in CSF between any other neurodegenerative groups and controls. These results suggest a specific increase in KYNA concentration in CSF from AD patients not seen in other neurodegenerative diseases.
PB MDPI
SN 2218-273X
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/117626
UL https://hdl.handle.net/20.500.14352/117626
LA eng
NO González-Sánchez, M., Jiménez, J., Narváez, A., Antequera, D., Llamas-Velasco, S., Martín, A. H.-S., Molina Arjona, J. A., López de Munain, A., Lleó Bisa, A., Marco, M.-P., Rodríguez-Núñez, M., Pérez-Martínez, D. A., Villarejo-Galende, A., Bartolome, F., Domínguez, E., & Carro, E. (2020). Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients. Biomolecules, 10(4), 571. https://doi.org/10.3390/biom10040571
NO Fondos FEDER
NO Instituto de Salud Carlos III (España)
NO Ministerio de Ciencia e Innovación (España)
NO Comunidad Autónoma de Madrid
NO European Commission
DS Docta Complutense
RD 4 ago 2025