RT Journal Article
T1 Versatile theranostics agents designed by coating ferrite nanoparticles with biocompatible polymers
A1 Zahraei, Maryam
A1 Marciello, Marzia
A1 Lázaro Carrilo, Ana
A1 Villanueva Oroquieta, Ángeles
A1 Herranz Rabanal, Fernando
A1 Talelli, Marina
A1 Costo, R.
A1 Monshi, Ahmad
A1 Shahbazi-Gahrouei, Daryoush
A1 Amirnasr, Mehdi
A1 Behdadfar, Behshid
A1 Puerto Morales Herrero, María Del
AB Three biocompatible polymers, polyethylene glycol (PEG), dextran and chitosan, have been used in this work to control the colloidal stability of magnetic nanoparticles (14 ± 5 nm in diameter) and to vary the aggregation state in order to study their effect on relaxometric and  heating properties. Two different coating strategies have been deeply developed; one based on the formation of an amide bond between citric acid coated nanoparticles (NPs) and amine groups present on the polymer surface and the other based on the NP encapsulation. Relaxometric properties revealed that proton relaxation rates strongly depend on the coating layer hydrophilicity and the aggregation state of the particles due to the presence of magnetic interactions. Thus, while PEG coating reduces particle aggregation by increasing inter-particle spacing leading to reduction of both T1 and T2 relaxation, dextran and chitosan lead to an increase mainly in T2 values due to the aggregation of particles in bigger clusters where they are in close contact. Dextran and chitosan coated NPs have also shown a remarkable heating effect during the application of an alternating magnetic field. They have proved to be potential candidates as theranostic agents for cancer diagnosis and treatment. Finally, cytotoxicity of PEG conjugated NPs, which seem to be ideal for intravenous administration because of their small hydrodynamic size, was investigated resulting in high cell viability even at 0.2 mg Fe ml−1 after 24 h of incubation. This suspension can be used as drug/biomolecule carrier for in vivo applications.
SN 0957-4484
YR 2016
FD 2016-05-17
LK https://hdl.handle.net/20.500.14352/100781
UL https://hdl.handle.net/20.500.14352/100781
LA eng
NO Zahraei, M., et al. «Versatile theranostics agents designed by coating ferrite nanoparticles with biocompatible polymers». Nanotechnology, vol. 27, n.o 25, junio de 2016, p. 255702. DOI.org (Crossref), https://doi.org/10.1088/0957-4484/27/25/255702.
NO Isfahan University of Technology (Iran)
NO European Commission
DS Docta Complutense
RD 7 abr 2025