%0 Journal Article
%A Paris, J.L.
%A Manzano García, Miguel
%A Cabañas Criado, María Victoria
%A Vallet Regí, María Dulce Nombre
%T Mesoporous Silica Nanoparticles Engineered for Ultrasound-Induced Uptake by Cancer Cells
%D 2018
%@ 2040-3364
%U https://hdl.handle.net/20.500.14352/11978
%X A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is here presented. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively-charged surface. That favors the internalization in human osteosarcoma cells, where release of topotecan takes place, drastically enhancing the cytotoxic effect.
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