RT Journal Article
T1 Mesoporous Silica Nanoparticles Engineered for Ultrasound-Induced Uptake by Cancer Cells
A1 Paris, J.L.
A1 Manzano García, Miguel
A1 Cabañas Criado, María Victoria
A1 Vallet Regí, María Dulce Nombre
AB A novel smart hierarchical ultrasound-responsive mesoporous silica nanocarrier for cancer therapy is here presented. This dynamic nanosystem has been designed to display different surface characteristics during its journey towards tumor cells. Initially, the anticancer-loaded nanocarriers are shielded with a polyethylene glycol layer. Upon exposure to high frequency ultrasound, the polymer shell detaches from the nanoparticles, exposing a positively-charged surface. That favors the internalization in human osteosarcoma cells, where release of topotecan takes place, drastically enhancing the cytotoxic effect.
PB Royal Society of Chemistry
SN 2040-3364
YR 2018
FD 2018-02-27
LK https://hdl.handle.net/20.500.14352/11978
UL https://hdl.handle.net/20.500.14352/11978
LA spa
NO RESEARCHER ID D-9318-2017 (Juan Luis Paris de la Fuente)ORCID 0000-0001-8950-283X (Juan Luis Paris de la Fuente)RESEARCHER ID K-3719-2014 (Miguel Manzano García)ORCID 0000-0001-6238-6111 (Miguel Manzano García)RESEARCHER ID G-8740-2015 (María Victoria Cabañas Criado)ORCID 0000-0002-4753-5665 (María Victoria Cabañas Criado)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 5 abr 2025