RT Journal Article
T1 Deposits of topical norfloxacin in the treatment of bacterial keratitis
A1 Castillo, Alfredo
A1 Benítez Del Castillo Sánchez, José Manuel
A1 Toledano, Nicolás
A1 Díaz Valle, David
A1 Sayagues, Octavio
A1 Garcia Sánchez, Julián
AB Purpose. Fluoroquinolone solutions are widely used in therapy of bacterial keratitis. These drugs are safe, and their ocular side effects are mild and not serious in nature. The most frequent untoward effect associated with ciprofloxacin therapy has been a white crystalline deposit. This deposit has not been reported after using the other commercially available quinolones, ofloxacin and norfloxacin. Methods. We present three cases of norfloxacin deposits after treatment of bacterial keratitis. Results. In the three cases, the norfloxacin was substituted for another antibiotic effective against the bacteria, and the precipitate spontaneously resolved in all cases within a few days with no untoward ocular effect. Conclusion. Crystalline corneal deposits can develop during topical norfloxacin therapy. The exact factors contributing to the formation are unknown, although the differences in the tear pH/solubility could be involved. Clinicians should be aware of this ocular side effect.
PB Lippincott, Williams & Wilkins
SN 0277-3740
YR 1997
FD 1997-04-16
LK https://hdl.handle.net/20.500.14352/112587
UL https://hdl.handle.net/20.500.14352/112587
LA eng
NO Castillo A, Benitez del Castillo JM, Toledano N, Diaz-Valle D, Sayagues O, Garcia-Sanchez J. Deposits of topical norfloxacin in the treatment of bacterial keratitis. Cornea. 1997 Jul;16(4):420-3.
DS Docta Complutense
RD 9 abr 2025