RT Journal Article
T1 Centrosome Polarization in T Cells: A Task for Formins
A1 Andrés-Delgado, Laura
A1 Antón Hurtado, Olga María
A1 Alonso, Miguel Angel
AB T-cell antigen receptor (TCR) engagement triggers the rapid reorientation of the centrosome, which is associated with the secretory machinery, toward the immunological synapse (IS) for polarized protein trafficking. Recent evidence indicates that upon TCR triggering the INF2 formin, together with the formins DIA1 and FMNL1, promotes the formation of a specialized array of stable detyrosinated MTs that breaks the symmetrical organization of the T-cell microtubule (MT) cytoskeleton. The detyrosinated MT array and TCR-induced tyrosine phosphorylation should coincide for centrosome polarization. We propose that the pushing forces produced by the detyrosinated MT array, which modify the position of the centrosome, in concert with Src kinase dependent TCR signaling, which provide the reference frame with respect to which the centrosome reorients, result in the repositioning of the centrosome to the IS.
PB Frontiers
SN 1664-3224
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/97009
UL https://hdl.handle.net/20.500.14352/97009
LA eng
NO Andrés-Delgado L, Antón OM and Alonso MA (2013) Centrosome polarization in T cells: a task for formins. Front. Immunol. 4:191. doi: 10.3389/fimmu.2013.00191
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 7 abr 2026