RT Journal Article T1 PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions A1 Hurtado Carneiro, Verónica A1 Pérez García, Ana A1 Álvarez García, Elvira A1 Sanz Miguel, María Del Carmen AB The protein kinase with PAS domains (PASK) is a nutrient and energy sensor located in the cells of multiple organs. Many of the recent findings for understanding PASK functions in mammals have been reported in studies involving PASK-deficient mice. This minireview summarizes the PASK role in the control of fasting and feeding responses, focusing especially on the hypothalamus and liver. In 2013, PASK was identified in the hypothalamic areas involved in feeding behavior, and its expression was regulated under fasting/refeeding conditions. Furthermore, it plays a role in coordinating the activation/inactivation of the hypothalamic energy sensors AMPK and mTOR/S6K1 pathways in response to fasting. On the other hand, PASK deficiency prevents the development of obesity and non-alcoholic fatty liver in mice fed with a high-fat diet. This protection is explained by the re-establishment of several high-fat diet metabolic alterations produced in the expression of hepatic transcription factors and key enzymes that control the main metabolic pathways involved in maintaining metabolic homeostasis in fasting/feeding responses. This minireview covers the effects of PASK inactivation in the expression of certain transcription factors and target enzymes in several metabolic pathways under situations such as fasting and feeding with either a standard or a high-fat diet. PB Frontiers SN 1664-2392 YR 2020 FD 2020-12-18 LK https://hdl.handle.net/20.500.14352/107701 UL https://hdl.handle.net/20.500.14352/107701 LA eng NO Hurtado-Carneiro V, Pérez-García A, Alvarez E and Sanz C (2020) PAS Kinase: A Nutrient and Energy Sensor “Master Key” in the Response to Fasting/Feeding Conditions. Front. Endocrinol. 11:594053. doi: 10.3389/fendo.2020.594053 NO Universidad Complutense de Madrid NO Banco Santander DS Docta Complutense RD 16 abr 2025