%0 Journal Article
%A Perez-Roman, Inés
%A Kiekens, Filip
%A Córdoba Díaz, Damián
%A García Rodríguez, Juan José
%A Córdoba Díaz, Manuel
%T Development of a Solid Formulation Containing a Microemulsion of a Novel Artemisia Extract with Nematocidal Activity for Oral Administration
%D 2020
%U https://hdl.handle.net/20.500.14352/115514
%X Background: Intestinal nematode infections are usually treated with benzimidazole drugs,but the emergence of resistance to these drugs has led to an increasing demand of new anthelminticstrategies. A new microemulsion formulation (ME) consisting of an Artemisia absinthium extractwith proven nematocidal efficacy was previously developed. The aim of our study is to implementa D-optimal mixture design methodology to increase the amount of a silica material (loaded withthis ME) in a tablet formulation, considering its tensile strength and disintegration time. Methods:16 experiments or combinations of the 6 tablet components (loaded silica, microcrystalline cellulose,polyvinylpyrrolidone, croscarmellose, Syloid® 244 FP and magnesium stearate) were assessed. Tensilestrength and disintegration time models were developed, and an optimization process was carriedout. Results: Tensile strength was improved by increasing the polyvinylpyrrolidone content, whilecroscarmellose decreased the disintegration time. The optimized powder mixture contains 49.7% w/wof the loaded silica material. A compression force of 12 kN was applied to the powder mixture to formtablets with a tensile strength of 2.0 MPa and a disintegration time of 3.8 min. Conclusions: Our resultsshow that D-optimal mixture designs provide a promising approach to formulate liquid-loadedsilica materials.
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