RT Journal Article
T1 Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people
A1 del Ser, Teodoro
A1 Zea, María Ascensión
A1 Valentí, Meritxell
A1 Olazarán Rodríguez, Francisco Javier
A1 López Álvarez, Jorge
A1 Rebollo Vázquez, Ana
A1 Ávila Villanueva, Marina
A1 Frades, Belén
A1 Medina, Miguel
A1 Fernández Blázquez, Miguel Ángel
AB Background:Chronic drug intake has been associated with negative and positive cognitive effects in elderly people, although subjacent conditions may be confounding factors.Aim:To study the effects on cognitive performance of commonly prescribed medications in a cohort of cognitively normal older adults.Methods:Medication intake was recorded during two years in 1087 individuals 70–85 years old, without neurological or psychiatric conditions. The influence of every drug, drug family and therapeutic group on six cognitive scores and on the conversion to mild cognitive impairment over two years was ascertained by cross-sectional and longitudinal analyses controlling for demographic and clinical variables.Results:Small effects of several drugs on information processing were found in cross-sectional analyses but only confirmed for a positive effect of vitamin D in case–control analyses. Longitudinal analyses showed no drug effects on the cognitive slopes. Several hypotensive drugs reduced, whereas bromazepam and glucose lowering drugs increased, the conversion rate to mild cognitive impairment with very small effects (R2=0.3–1%).Conclusions:Cognitively healthy elderly individuals show minimal negative effects on information processing associated with chronic intake of some drugs probably related to the subjacent condition. Some drugs slightly affect the rate of conversion to mild cognitive impairment. Positive effects of vitamin D, chondroitin, atorvastatin and antihypertensive drugs, and negative effects of antidepressants and benzodiazepines, should be further explored in studies with longer follow-up.
PB Sage Journals
SN 0269-8811
YR 2019
FD 2019-08-03
LK https://hdl.handle.net/20.500.14352/132691
UL https://hdl.handle.net/20.500.14352/132691
LA eng
NO Del Ser, T., Zea, M.-A., Valentí, M., Olazarán, J., López-Álvarez, J., Rebollo-Vázquez, A., Ávila-Villanueva, M., Frades, B., Medina, M., & Fernández-Blázquez, M. A. (2019). Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people. Journal of Psychopharmacology, 33(8), 965-974. https://doi.org/10.1177/0269881119857206
DS Docta Complutense
RD 26 feb 2026