RT Journal Article
T1 Physical Stability Studies of Semi-Solid Formulations from Natural Compounds Loaded with Chitosan Microspheres
A1 Acosta Contreras, Niuris
A1 Sánchez, Elisa
A1 Calderón, Laura
A1 Córdoba Díaz, Manuel
A1 Córdoba Díaz, Damián
A1 Dom, Senne
A1 Heras Caballero, Ángeles
AB A chitosan-based hydrophilic system containing an olive leaf extract was designed and its antioxidant capacity was evaluated. Encapsulation of olive leaf extract in chitosan microspheres was carried out by a spray-drying process. The particles obtained with this technique were found to be spherical and had a positive surface charge, which is an indicator of mucoadhesiveness. FTIR and X-ray diffraction results showed that there are not specific interactions of polyphenolic compounds in olive leaf extract with the chitosan matrix. Stability and release studies of chitosan microspheres loaded with olive leaf extract before and after the incorporation into a moisturizer base were performed. The resulting data showed that the developed formulations were stable up to three months. The encapsulation efficiency was around 44% and the release properties of polyphenols from the microspheres were found to be pH dependent. At pH 7.4, polyphenols release was complete after 6 h; whereas the amount of polyphenols released was 40% after the same time at pH 5.5.
PB MDPI
SN 1660-3397
YR 2015
FD 2015-09-16
LK https://hdl.handle.net/20.500.14352/23891
UL https://hdl.handle.net/20.500.14352/23891
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 30 abr 2024