RT Journal Article
T1 Fermentative factors shape transcriptional response of Lachancea thermotolerans and wine acidification
A1 Vicente Sánchez, Javier
A1 Santiago Benito Saez, 
A1 Marquina Díaz, Domingo
A1 Santos de la Sen, Antonio
AB Climate change is affecting grape must composition by increasing sugars and reducing organic acids, leading to sluggish fermentations and lower wine quality. Among biological solutions, Lachancea thermotolerans is widely studied for its ability to improve acidity through lactic acid production. This study evaluated how biotic and abiotic factors relevant to climate change influence both wine acidification and the transcriptomic response of L. thermotolerans. We assessed the effects of varying sugar concentrations, pH levels, and organic/inorganic nitrogen ratios, individually and combined. Additionally, we examined how fermentative partners (Saccharomyces cerevisiae and Schizosaccharomyces pombe) affect L. thermotolerans during co-fermentations. Results showed enhanced lactic acid production under high sugar and low organic nitrogen, with Sch. pombe promoting acidification and S. cerevisiae reducing it. These findings provide key insights into the metabolic response of L. thermotolerans and highlight the need to manage fermentation conditions and microbial interactions to improve wine quality in the face of climate change.
PB Springer Nature
SN 2396-8370
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/122348
UL https://hdl.handle.net/20.500.14352/122348
LA eng
NO Vicente, J., Benito, S., Marquina, D. et al. Fermentative factors shape transcriptional response of Lachancea thermotolerans and wine acidification. npj Sci Food 9, 97 (2025). https://doi.org/10.1038/s41538-025-00467-y
NO Funding for this research was provided by the LowpHWine Companies Consortia through the CDTI project LowpHWine (IDI-20210391) and the Spanish Ministry of Science and Innovation under the VinSegCalClim project (PID2020-119008RB-I00/AEI/10.13039/501100011033). The funder played no role in study design, data collection, analysis and interpretation of data, or the writing of this manuscript. J.V. conducted this research under a fellowship from Complutense University of Madrid (CT58/21-CT59/21).
NO LowpHWine
NO Ministerio de Ciencia e Innovación (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 16 jul 2025