RT Book, Section
T1 Two Distinct Signals Determine the Basolateral Targeting of AQP4 in the Renal Epithelial Cell Line MDCK
A1 Madrid González, Ricardo
A1 Le Maout, Sophie
A1 Barrault, Marie-Bénédicte
A1 Mérot, Jean
AB To fulfill their physiological role in water handling by the kidney, aquaporins are differentially targeted to the apical and the basolateral membranes of epithelial kidney cells. For example, whereas AQP1 exhibits an un-polarized distribution in the proximal tubule cells (Sabolic et al., 1992,Nielsen et al., 1993), AQP2 is specifically targeted to the apical membranes of the principal cells in the collecting duct (Fushimi et al., 1993,Nielsen et al., 1993). On the other hand, AQP3 and AQP4 are exclusively localized in the basolateral membranes of these cells (Ecelbarger et al., 1995,Frigeri et al., 1995). Although a great deal of information about the cellular distribution of aquaporins in the body has emerged from previous studies, the mechanisms underlying their targeting in polarized epithelial cells remain poorly understood.
PB Springer Link
SN 978-1-4613-5439-0
SN 978-1-4615-1203-5
YR 2000
FD 2000
LK https://hdl.handle.net/20.500.14352/97570
UL https://hdl.handle.net/20.500.14352/97570
LA eng
NO Madrid, R., Le Maout, S., Barrault, MB., Mérot, J. (2000). Two Distinct Signals Determine the Basolateral Targeting of AQP4 in the Renal Epithelial Cell Line MDCK. In: Hohmann, S., Nielsen, S. (eds) Molecular Biology and Physiology of Water and Solute Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1203-5_22
DS Docta Complutense
RD 13 abr 2025