RT Journal Article
T1 Functional coatings enable navigation of light-propelled micromotors in blood for effective biodetoxification
A1 Pacheco, Marta
A1 Jurado-Sánchez, Beatriz
A1 Escarpa, Alberto
AB Herein we report the coating of visible light-driven polycaprolactone (PCL) based micromotors with an anti-biofouling poly lactic-co-glycolic acid (PLGA) layer for effective navigation and detoxification in blood samples. The micromotors encapsulate CdSe@ZnS quantum dots as photoresponsive materials and a Fe3O4 nanoparticle patch to promote electron transfer and reaction with glucose present in the media for diffusiophoretic propulsion in diluted blood. The coating of the micromotor with the PLGA layer prevents red blood cell adhesion and protein adsorption due to the creation of a highly efficient hydration layer. This results in an enhanced speed and efficient operation for enhanced toxin removal as compared with the bare PCL micromotors. Hemolysis and MTT assays along with no platelets aggregation revealed the high biocompatibility of the micromotors with living cells. Effective adsorptive removal of two relevant toxins, sepsis associated Escherichia coli O111:B4 toxin and snake venom α-bungarotoxin from blood is achieved with the PLGA micromotors. The new developments illustrated here represent one step forward in the use of light-driven micromotors for biomedical applications.
PB Royal Society Chemistry
SN 2040-3364
YR 2021
FD 2021-10-05
LK https://hdl.handle.net/20.500.14352/93670
UL https://hdl.handle.net/20.500.14352/93670
LA eng
NO 4.	M. Pacheco, B. Jurado-Sánchez*, A. Escarpa*. Functional coating enable navigation of light-propelled micromotors in blood for effective biodetoxification. Nanoscale, 2021, 13, 17106-17115.
NO Spanish Ministry of Economy, Industry and Competitiveness
NO Spanish Ministry of Education and Universities
NO Spanish Ministry of Science and Innovation
NO Community of Madrid
DS Docta Complutense
RD 10 abr 2025