RT Journal Article
T1 BF 2 -azadipyrromethene NIR-emissive fluorophores with research and clinical potential
A1 Daly, Harrison
A1 Durán Sampedro, Gonzalo
A1 Bon, Corentin
A1 Wu, Dan
A1 Ismail, Ghazi
A1 Cahill, Ronan
A1 O'Shea, Donal
AB The use of near-infrared fluorescence for in vivo research and intraoperative clinical imaging is rapidly expanding, with new applications being proposed and developed. While imaging hardware and software have significantly progressed in recent times, the molecular fluorescent agents remain a limiting factor. In this report, the design, synthesis, photophysical characterization and bio-medical imaging assessment of two new NIR-fluorophores based on the BF2-azadipyrromethene fluorophore class are described. Inclusion of dimethylamino substituents on these BF2-azadipyrromethene probes results in very large bathochromic shifts with photophysical measurements showing absorption and emission maxima between 757 and 818 nm within the desired NIR spectra region. Testing of the probes shows that they are suitable for fluorescence imaging with both research and clinical instrumentation. Preclinical imaging assessment shows their suitability as fluorescent markers (tattoos) of lesions for intraoperative identification and lymphatic mapping in ex vivo human colonic tissue. These new clinical wavelength-compatible fluorophores may contribute towards the on-going expansion of medical uses for NIR-fluorescence.
PB Elsevier Ltd.
SN 0223-5234
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/95512
UL https://hdl.handle.net/20.500.14352/95512
LA eng
NO Daly, Harrison C., et al. «BF 2 -Azadipyrromethene NIR-Emissive Fluorophores with Research and Clinical Potential». European Journal of Medicinal Chemistry, vol. 135, julio de 2017, pp. 392-400. https://doi.org/10.1016/j.ejmech.2017.04.051.
NO Science Foundation Ireland
DS Docta Complutense
RD 5 abr 2025