RT Journal Article
T1 Subtilase cytotoxin-encoding subAB2 variants in verotoxin-producing Escherichia coli strains isolated from goats and sheep
A1 Orden Gutiérrez, José Antonio
A1 Domínguez Bernal, Gustavo Ramón
A1 Fuente López, Ricardo De La
A1 Carrión Herrero, Francisco Javier
AB Subtilase cytotoxin (SubAB) is a cytotoxin which might contribute to the virulence of verotoxin-producing Escherichia coli (VTEC) strains in humans. Three variants of SubAB encoding genes have been described (subAB1, subAB2-1, and subAB2-2) and it has been suggested that the strains positive for two variants of subAB may be more pathogenic for humans. In this study, 188 subAB2-positive VTEC strains isolated from goats and sheep were investigated for the presence of the subAB2-1 and subAB2-2 variants by PCR. Eighty-one of the 132 (61.4%) caprine strains and 36 of the 56 (64.3%) ovine strains possessed the subAB2-1 variant and all ovine and caprine strains, except one, were positive for the subAB2-2 variant. The results of this study show for first time that the subAB2-1 and subAB2-2 variants are found in caprine subAB2-positive VTEC strains and confirm that both subAB2 variants are detected in ovine subAB2-positive VTEC strains. Since no significant difference in the presence of both subAB2 variants was found among strains belonging to serotypes associated with severe illness in humans and strains not belonging to these serotypes, the occurrence of two subAB2 variants seems not to be associated with a higher risk of severe disease in humans.
PB Elsevier
SN 0034-5288
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/93839
UL https://hdl.handle.net/20.500.14352/93839
LA eng
NO Orden, J. A., Domínguez-Bernal, G., de la Fuente, R., & Carrión, J. (2016). Subtilase cytotoxin-encoding subAB2 variants in verotoxin-producing Escherichia coli strains isolated from goats and sheep. Research in veterinary science, 105, 74–76. https://doi.org/10.1016/j.rvsc.2016.01.017
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 4 abr 2025