RT Journal Article
T1 Senescent Microvesicles: A Novel Advance in Molecular Mechanisms of Atherosclerotic Calcification
A1 Alique, Matilde
A1 Ramírez-Carracedo, Rafael
A1 Bodega, Guillermo
A1 Carracedo Añón, Julia María
A1 Ramírez, Rafael
AB Atherosclerosis, a chronic inflammatory disease that causes the most heart attacks and strokes in humans, is the leading cause of death in the developing world; its principal clinical manifestation is coronary artery disease. The development of atherosclerosis is attributed to the aging process itself (biological aging) and is also associated with the development of chronic diseases (premature aging). Both aging processes produce an increase in risk factors such as oxidative stress, endothelial dysfunction and proinflammatory cytokines (oxi-inflamm-aging) that might generate endothelial senescence associated with damage in the vascular system. Cellular senescence increases microvesicle release as carriers of molecular information, which contributes to the development and calcification of atherosclerotic plaque, as a final step in advanced atherosclerotic plaque formation. Consequently, this review aims to summarize the information gleaned to date from studies investigating how the senescent extracellular vesicles, by delivering biological signalling, contribute to atherosclerotic calcification.
PB MDPI
SN 1422-0067
YR 2018
FD 2018-07-09
LK https://hdl.handle.net/20.500.14352/12490
UL https://hdl.handle.net/20.500.14352/12490
LA eng
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Red de Investigación Renal
NO Junta de Andalucía
NO Universidad Complutense de Madrid/Bnco de Santander
NO Universidad de Alcalá
DS Docta Complutense
RD 10 may 2025