RT Journal Article
T1 Polymeric Nanozyme with SOD Activity Capable of Inhibiting Self- and Metal-Induced α-Synuclein Aggregation
T2 Nanoenzimas poliméricos con actividad SOD capades de inhibir la agregación auto- o metal-inducida de α-sinucleina
A1 Martínez Camarena, Álvaro
A1 Bellia, Francesco
A1 Clares García, María Paz
A1 Vecchio, Graziella
A1 Nicolas, Julien
A1 García-España, Enrique
AB Despite decades of research, Parkinson's disease is still an idiopathic pathology for which no cure has yet been found. This is partly explained by the multifactorial character of most neurodegenerative syndromes, whose generation involves multiple pathogenic factors. In Parkinson's disease, two of the most important ones are the aggregation of α-synuclein and oxidative stress. In this work, we address both issues by synthesizing a multifunctional nanozyme based on grafting a pyridinophane ligand that can strongly coordinate CuII, onto biodegradable PEGylated polyester nanoparticles. The resulting nanozyme exhibits remarkable superoxide dismutase activity together with the ability to inhibit the self-induced aggregation of α-synuclein into amyloid-type fibrils. Furthermore, the combination of the chelator and the polymer produces a cooperative effect whereby the resulting nanozyme can also halve CuII-induced α-synuclein aggregation.
PB Wiley
YR 2024
FD 2024-04-30
LK https://hdl.handle.net/20.500.14352/104896
UL https://hdl.handle.net/20.500.14352/104896
LA eng
NO Á. Martínez-Camarena, F. Bellia, M. Paz Clares, G. Vecchio, J. Nicolas, E. García-España, Chem. Eur. J. 2024, e202401331. https://doi.org/10.1002/chem.202401331
DS Docta Complutense
RD 7 abr 2025