%0 Journal Article
%A Arumugam, Natarajan
%A Almansour, Abdulrahman I.
%A Suresh Kumar, Raju
%A Govindasami, Periyasami
%A Al-thamili, Dhaifallah
%A Krishnamoorthy, Rajapandian
%A Periasamy, Vaiyapuri Subbarayan
%A Alshatwi, Ali
%A Mahalingam, S. M.
%A Thangamani, Shankar
%A Menéndez Ramos, José Carlos
%T Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines
%D 2018
%@ 1420-3049
%U https://hdl.handle.net/20.500.14352/12717
%X A series of spirooxindolopyrrolidine fused N -styrylpiperidone heterocyclic hybrids has been synthesized in excellent yield via a domino multicomponent protocol that involves one-pot three component 1,3-dipolar cycloaddition and concomitant enamine reactions performed in an inexpensive ionic liquid, namely 1-butyl-3-methylimidazolium bromide ([bmim]Br). Compounds thus synthesized were evaluated for their cytotoxicity against U-937 tumor cells. Interestingly; compounds 5i and 5m exhibited a better cytotoxicity than the anticancer drug bleomycin. In ddition; the effect of the synthesized compounds on the nuclear morphology of U937 FaDu cells revealed that treatment with compounds 5a–m led to their apoptotic cell death.
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