RT Journal Article
T1 Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines
A1 Arumugam, Natarajan
A1 Almansour, Abdulrahman I.
A1 Suresh Kumar, Raju
A1 Govindasami, Periyasami
A1 Al-thamili, Dhaifallah
A1 Krishnamoorthy, Rajapandian
A1 Periasamy, Vaiyapuri Subbarayan
A1 Alshatwi, Ali
A1 Mahalingam, S. M.
A1 Thangamani, Shankar
A1 Menéndez Ramos, José Carlos
AB A series of spirooxindolopyrrolidine fused N -styrylpiperidone heterocyclic hybrids has been synthesized in excellent yield via a domino multicomponent protocol that involves one-pot three component 1,3-dipolar cycloaddition and concomitant enamine reactions performed in an inexpensive ionic liquid, namely 1-butyl-3-methylimidazolium bromide ([bmim]Br). Compounds thus synthesized were evaluated for their cytotoxicity against U-937 tumor cells. Interestingly; compounds 5i and 5m exhibited a better cytotoxicity than the anticancer drug bleomycin. In ddition; the effect of the synthesized compounds on the nuclear morphology of U937 FaDu cells revealed that treatment with compounds 5a–m led to their apoptotic cell death.
PB MDPI
SN 1420-3049
YR 2018
FD 2018-05-05
LK https://hdl.handle.net/20.500.14352/12717
UL https://hdl.handle.net/20.500.14352/12717
LA eng
NO Deanship of Scientific Research at King Saud University
DS Docta Complutense
RD 12 abr 2025