RT Journal Article
T1 Influence of the decrease in ciprofloxacin susceptibility and the presence of human serum on the in vitro susceptibility of Streptococcus pneumoniae to five new quinolones
A1 Balcabao, Ignacio P.
A1 Alou Cervera, Luis
A1 Aguilar, Lorenzo
A1 Gómez-Lus Centelles, María Luisa
A1 Giménez, María José
A1 Prieto Prieto, José
AB Sixty recent Streptococcus pneumoniae isolates with different susceptibilities to ciprofloxacin (14 with MIC 0.5 mg/L, 10 with MIC 1 mg/L, eight with MIC 2 mg/L, 11 with MIC 4 mg/L and 17 with MIC > or =8 mg/L) were tested against five new quinolones using Todd-Hewitt broth with and without 80% serum. The final inoculum was 5 x 10(5) cfu/mL. Gemifloxacin and clinafloxacin exhibited the lowest MIC90 values and resistance rates (percentage above and defined breakpoint) with and without serum for strains with a ciprofloxacin MIC of > or =4 mg/L. Other quinolones tested were less active against strains with reduced ciprofloxacin susceptibility. The presence of serum did not affect susceptibility to moxifloxacin, but increased the resistance rates to other new quinolones for strains with high ciprofloxacin MICs.
PB Oxford University Press
SN 0305-7453
YR 2001
FD 2001-12-01
LK https://hdl.handle.net/20.500.14352/107188
UL https://hdl.handle.net/20.500.14352/107188
LA eng
NO Balcabao IP, Alou L, Aguilar L, Gomez-Lus ML, Giménez MJ, Prieto J. Influence of the decrease in ciprofloxacin susceptibility and the presence of human serum on the in vitro susceptibility of Streptococcus pneumoniae to five new quinolones. J Antimicrob Chemother. 2001 Dec;48(6):907-9.
NO SmithKline Beecham, S.A.
DS Docta Complutense
RD 22 dic 2025