RT Journal Article
T1 Nanotechnological Strategies for Protein Delivery
A1 Villegas Díaz, María Rocío
A1 Baeza, Alejandro
A1 Vallet Regí, María Dulce Nombre
AB The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target. Moreover, several proteins are unable to cross the cell membrane. All these facts strongly hinder their therapeutic effect. Nanomedicine has emerged as a powerful tool which can provide solutions to solve these limitations and improve the efficacy of treatments based on protein administration. This review discusses the advantages and limitations of different types of strategies employed for protein delivery, such as PEGylation, transport within liposomes or inorganic nanoparticles or their in situ encapsulation.
PB MDPI
SN 1420-3049
YR 2018
FD 2018-04-25
LK https://hdl.handle.net/20.500.14352/12066
UL https://hdl.handle.net/20.500.14352/12066
LA eng
NO RESEARCHER ID V-7077-2017 (María Rocío Villegas Díaz)ORCID 0000-0002-1297-2355 (María Rocío Villegas Díaz)RESEARCHER ID K-8193-2014 (Alejandro Baeza)ORCID 0000-0002-2026-6266 (Alejandro Baeza)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 27 abr 2024