RT Journal Article
T1 The role of T cells in age-related diseases
A1 Carrasco, Elisa
A1 Gómez de las Heras, Manuel
A1 Gabandé-Rodríguez, Enrique
A1 Desdín-Micó, Gabriela
A1 Aranda Gómez, Juan Francisco
A1 Mittelbrunn, Maria
AB Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that ‘resetting’ immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.
PB Nature Research
SN 1474-1733
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/93165
UL https://hdl.handle.net/20.500.14352/93165
LA eng
NO Carrasco, E., Gómez de las Heras, M.M., Gabandé-Rodríguez, E. et al. The role of T cells in age-related diseases. Nat Rev Immunol 22, 97–111 (2022). https://doi.org/10.1038/s41577-021-00557-4
NO European Commission
NO Instituto de Salud Carlos III
NO Universidad Autónoma de Madrid
DS Docta Complutense
RD 23 abr 2025