RT Journal Article
T1 A longitudinal study on the relationship between duration of untreated psychosis and executive function in early-onset first-episode psychosis
A1 Fraguas Herráez, David
A1 Merchán Naranjo, Jessica
A1 Del Rey Mejías, Ángel
A1 Castro Fornieles, Josefina
A1 González Pinto, Ana
A1 Rapado Castro, Marta
A1 Pina Camacho, Laura
A1 Díaz Caneja, Covadonga M.
A1 Graell, Montse
A1 Otero, Soraya
A1 Baeza, Inmaculada
A1 Moreno Ruiz, María del Carmen
A1 Martínez Cengoitabengoa, Mónica
A1 Rodríguez Toscano, Elisa
A1 Arango López, Celso
A1 Parellada Redondo, María José
AB Background: The relationship between duration of untreated psychosis (DUP) and executive function (EF) in patients with first-episode psychosis (FEP) is controversial.We aimto assess the influence of DUP on changes in EF over a 2-year period in subjects with early-onset FEP (first psychotic symptom before age 18) and less than 6 months of positive symptoms.Methods: A total of 66 subjects were included in the study (19 females [28.8%], mean age 16.2± 1.6 years). The influence of DUP on changes in EF over the 2-year follow-up (expressed as a composite score of 5 cognitive abilities: attention, working memory, cognitive flexibility, response inhibition, and problem solving) was estimated using amultivariate linear regressionmodel after removing the effect of intelligence quotient and controlling for age, gender, diagnosis, premorbid adjustment, severity of positive and negative symptoms at baseline, global functioning at baseline, and mean daily antipsychotic dosage during follow-up.Results: Mean DUP was 65.0 ± 6.9 days (95% confidence interval [CI], 51.2, 78.8). Median DUP was 47.5 days (range 2–180 days). Negative symptoms at baseline was the only variable significantly associated with EF at baseline (10.9% of explained variance [e.v. 10.9%], p= 0.007). Only shorter DUP (e.v. 8.7%, p= 0.013) and greater severity of baseline negative symptoms (e.v. 10.0%, p= 0.008) were significantly associated with greater improvement in EF.Conclusions: In early-onset FEP, shorterDUPwas associatedwith greater improvement in EF over a 2-year followup period.
PB Springer
SN 0920-9964
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/114220
UL https://hdl.handle.net/20.500.14352/114220
LA eng
NO Fraguas, D., Merchán Naranjo, J., Del Rey Mejías, Á., Castro Fornieles, J., González Pinto, A., Rapado Castro, M., Pina Camacho, L., Díaz Caneja, C. M., Graell, M., Otero, S., Baeza, I., Moreno, C., Martínez Cengotitabengoa, M., Rodríguez Toscano, E., Arango, C., & Parellada, M. (2014). A longitudinal study on the relationship between duration of untreated psychosis and executive function in early-onset first-episode psychosis. Schizophrenia Research, 158(1-3), 126-133. https://doi.org/10.1016/j.schres.2014.06.038
DS Docta Complutense
RD 4 abr 2025