RT Book, Section T1 Anatomy of the Human Optic Nerve: Structure and Function A1 Salazar Corral, Juan José A1 Ramírez Sebastián, Ana Isabel A1 Hoz Montañana, María Rosa De A1 García Martín, Elena Salobrar A1 Rojas Lozano, María Del Pilar A1 Fernández Arrabal, José A. A1 López Cuenca, Inés A1 Rojas López, María Blanca A1 Triviño Casado, Alberto A1 Ramírez Sebastián, José Manuel A2 Ferreri, Felicia M. AB The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These axons are distributed in an organized pattern from the soma of the RGC to the lateral geniculated nucleus (where most of the neurons synapse). The key points of the ON are the optic nerve head and chiasm. This chapter will include a detailed and updated review of the ON different parts: RGC axons, glial cells, connective tissue of the lamina cribrosa and the septum and the blood vessels derivate from the central retina artery and from the ciliary system. There will be an up-to-date description about the superficial nerve fibre layer, including their organization, and about prelaminar, laminar and retrolaminar regions, emphasizing the axoplasmic flow, glial barriers, biomechanics of the lamina cribrosa and the role of the macro- and microglia in their working. PB IntechOpen YR 2018 FD 2018-11 LK https://hdl.handle.net/20.500.14352/13983 UL https://hdl.handle.net/20.500.14352/13983 LA eng NO Salazar Corral, J. J., Ramírez Sebastián, A. I., Hoz Montañana, M. R. et al. «Anatomy of the Human Optic Nerve: Structure and Function». Optic Nerve, editado por Felicia M. Ferreri, IntechOpen, 2019. DOI.org (Crossref), https://doi.org/10.5772/intechopen.79827. NO Ministerio de Economía, Comercio y Empresa (España) NO Instituto de Salud Carlos III DS Docta Complutense RD 30 jun 2025