RT Journal Article
T1 The Role of Immune Cells in Oxi-Inflamm-Aging
A1 Martínez de Toda Cabeza, Irene
A1 Ceprián, Noemí
A1 Díaz Del Cerro, Estefanía
A1 Fuente del Rey, Mónica de la
AB Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.
PB MDPI
SN Electronic: 2073-4409
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/20.500.14352/4867
UL https://hdl.handle.net/20.500.14352/4867
LA eng
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Universidad Complutense de Madrid (UCM)
DS Docta Complutense
RD 8 abr 2025