RT Journal Article
T1 Corneal Segmentation Analysis Increases Glaucoma Diagnostic Ability of Optic Nerve Head Examination, Heidelberg Retina Tomograph's Moorfield's Regression Analysis, and Glaucoma Probability Score
A1 Sáenz Francés, Federico
A1 Jañez Escalada, Luis
A1 Berrozpe Villabona, Clara
A1 Borrego Sanz, Lara
A1 Morales Fernández, Laura
A1 Acebal Montero, Alejandra
A1 Méndez Hernández, Carmen D.
A1 Martínez De La Casa Fernández-Borrella, José María
A1 Santos Bueso, Enrique Miguel
A1 García Sánchez, Julián
A1 García Feijoo, Julián
AB Purpose. To study whether a corneal thickness segmentation model, consisting in a central circular zone of 1 mm radius centered at the corneal apex (zone I) and five concentric rings of 1 mm width (moving outwards: zones II to VI), could boost the diagnostic accuracy of Heidelberg Retina Tomograph's (HRT's) MRA and GPS. Material and Methods. Cross-sectional study. 121 healthy volunteers and 125 patients with primary open-angle glaucoma. Six binary multivariate logistic regression models were constructed (MOD-A1, MOD-A2, MOD-B1, MOD-B2, MOD-C1, and MOD-C2). The dependent variable was the presence of glaucoma. In MOD-A1, the predictor was the result (presence of glaucoma) of the analysis of the stereophotography of the optic nerve head (ONH). In MOD-B1 and MOD-C1, the predictor was the result of the MRA and GPS, respectively. In MOD-B2 and MOD-C2, the predictors were the same along with corneal variables: central, overall, and zones I to VI thicknesses. This scheme was reproduced for model MOD-A2 (stereophotography along with corneal variables). Models were compared using the area under the receiver operator characteristic curve (AUC). Results. MOD-A1-AUC: 0.771; MOD-A2-AUC: 0.88; MOD-B1-AUC: 0.736; MOD-B2-AUC: 0.845; MOD-C1-AUC: 0.712; MOD-C2-AUC: 0.838. Conclusion. Corneal thickness variables enhance ONH assessment and HRT's MRA and GPS diagnostic capacity.
PB HINDAWI PUBLISHING CORPORATION
SN 2090-004X
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/35393
UL https://hdl.handle.net/20.500.14352/35393
LA eng
NO Sáenz Francés, F., Jañez Escalada, L., Berrozpe Villabona, C. et al. «Corneal Segmentation Analysis Increases Glaucoma Diagnostic Ability of Optic Nerve Head Examination, Heidelberg Retina Tomograph’s Moorfield’s Regression Analysis, and Glaucoma Probability Score». Journal of Ophthalmology, vol. 2015, 2015, pp. 1-8. DOI.org (Crossref), https://doi.org/10.1155/2015/215951.
NO Received 1 March 2015; Accepted 5 May 2015
DS Docta Complutense
RD 21 jul 2024