%0 Journal Article
%A Andreu-Ballester, Juan Carlos
%A Catalán-Serra, Ignacio
%A Gil-Borrás, Rafael
%A Marqués-García, Pilar
%A García-Ballesteros, Carlos
%A López Chuliá, Francisco
%A Cuéllar Del Hoyo, María Del Carmen
%T Gammadelta T cells as a predictor of surgical relapse of Crohn's disease
%D 2020
%@ 2210-7401
%U https://hdl.handle.net/20.500.14352/101541
%X Background: We recently demonstrated a decrease in the overall lymphocyte population in the peripheral blood of patients with CD compared to healthy controls and this decrease is more evident in γδ T lymphocytes. The percentages of T cell subsets could reflect the risk of surgical relapse in CD patients. The aim of this study is to study the correlation between αβ and γδ T cell subsets in the peripheral blood of patients with CD and the risk for surgery during follow up.Methods: A prospective study of 102 patients with CD compared with 102 healthy subjects (control group) matched by age and sex was conducted. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, and αβ and γδ T cell subsets were measured in the peripheral blood of all participants.Results: We found evidence of a relationship between lower γδ T cell levels and risk of surgical relapse in CD. The lowest subsets observed in CD patients with surgical relapse were CD3 + γδ, CD3 + CD8 + γδ and CD3 + CD56 + γδ T cells. We observed a relationship between a decrease in γδ T cells and the most severe forms of the disease. The lowest levels of CD3 + γδ and CD3 + CD8 + γδ T cells were observed in the fistulizing phenotype.Conclusions: The deficit of γδ T cells was related with the severity and the risk for surgicalrelapse in CD patients. Patients with CD3 + γδ deficit were more prone to surgery than patientswithout this deficit. These results suggest that γδ T cells could be used as markers of poorprognosis of CD following the diagnosis of the disease.
%~