RT Journal Article
T1 Gammadelta T cells as a predictor of surgical relapse of Crohn's disease
A1 Andreu-Ballester, Juan Carlos
A1 Catalán-Serra, Ignacio
A1 Gil-Borrás, Rafael
A1 Marqués-García, Pilar
A1 García-Ballesteros, Carlos
A1 López Chuliá, Francisco
A1 Cuéllar Del Hoyo, María Del Carmen
AB Background: We recently demonstrated a decrease in the overall lymphocyte population in the peripheral blood of patients with CD compared to healthy controls and this decrease is more evident in γδ T lymphocytes. The percentages of T cell subsets could reflect the risk of surgical relapse in CD patients. The aim of this study is to study the correlation between αβ and γδ T cell subsets in the peripheral blood of patients with CD and the risk for surgery during follow up.Methods: A prospective study of 102 patients with CD compared with 102 healthy subjects (control group) matched by age and sex was conducted. Lymphocytic populations of CD3+, CD4+, CD8+, CD56+, and αβ and γδ T cell subsets were measured in the peripheral blood of all participants.Results: We found evidence of a relationship between lower γδ T cell levels and risk of surgical relapse in CD. The lowest subsets observed in CD patients with surgical relapse were CD3 + γδ, CD3 + CD8 + γδ and CD3 + CD56 + γδ T cells. We observed a relationship between a decrease in γδ T cells and the most severe forms of the disease. The lowest levels of CD3 + γδ and CD3 + CD8 + γδ T cells were observed in the fistulizing phenotype.Conclusions: The deficit of γδ T cells was related with the severity and the risk for surgicalrelapse in CD patients. Patients with CD3 + γδ deficit were more prone to surgery than patientswithout this deficit. These results suggest that γδ T cells could be used as markers of poorprognosis of CD following the diagnosis of the disease.
PB Elsevier
SN 2210-7401
YR 2020
FD 2020-09-20
LK https://hdl.handle.net/20.500.14352/101541
UL https://hdl.handle.net/20.500.14352/101541
LA eng
NO Andreu-Ballester JC, Catalán-Serra I, Gil-Borrás R, Marqués-García P, García-Ballesteros C, López Chuliá F, Cuéllar C. Gammadelta T cells as a predictor of surgical relapse of Crohn's disease. Clin Res Hepatol Gastroenterol. 2020 Sep;44(4):586-597. doi: 10.1016/j.clinre.2019.11.003. Epub 2019 Dec 18. PMID: 31864955.
DS Docta Complutense
RD 4 ago 2024