RT Journal Article
T1 Ganglia in the Human Fetal Lung
A1 Cho, Kwang Ho
A1 Kim, Ji Hyun
A1 Jin, Zhe Wu
A1 Abe, Hiroshi
A1 Murakami, Gen
A1 Rodríguez Vázquez, José Francisco
AB Although pulmonary ganglia were considered to be an analogue of the myenteric ganglia of intestines in embryos, there seemed to be no morphological evaluation in the later stage of development. We conducted immunostainings of intrapulmonary nerves using 17 human fetuses at 14-18 and 28-34 weeks. The ganglion cells were small (15-20 μm in diameter) in the earlier group, but they increased in size (20-30 μm) in the late group. One ganglion, containing 5-30 cell bodies, was usually located "outside" of the bronchial smooth muscle or cartilage. In addition, a few ganglion was found beneath the mucosa of the trachea and principal bronchi. The highest density of ganglia (5-15 ganglia per section with 50 μm interval) was found at the origin of the subsegmental bronchi, but ganglia were absent along more peripheral bronchi those are responsible for contraction and obstruction of the airway. Therefore, in topographical relation between smooth muscle and nerve, intrapulmonary intrinsic neurons were different from intestinal myenteric neurons. Consequently, a previous hypothesis of "embryonic intramuscular bronchial ganglia" seemed not to be based on observations of the peripheral bronchus but on the central bronchus than the sub-subsegmental level. An extrinsic migration and redistribution of ganglia might occur at midterm to provide the final location outside of airway smooth muscles. Finally, no ganglion cell bodies were positive either for neuronal nitric oxide synthase or tyrosine hydroxylase. Instead of the classical entity of autonomic nerves, nonadrenergic noncholinergic (NANC) innervation might be dominant even in fetuses.
PB Wiley
SN 1932-8486
YR 2019
FD 2019-07-16
LK https://hdl.handle.net/20.500.14352/109390
UL https://hdl.handle.net/20.500.14352/109390
LA eng
NO Cho KH, Kim JH, Jin ZW, Abe H, Murakami G, Rodríguez-Vázquez JF. Ganglia in the Human Fetal Lung. Anat Rec (Hoboken). 2019 Dec;302(12):2233-2244. doi: 10.1002/ar.24208
NO Ministerio de Educación, Cultura, Deportes, Ciencia y Tecnología (Japón)
DS Docta Complutense
RD 7 abr 2025