RT Journal Article
T1 Strong Wavelength Dependence of Hyperpolarizability in the Near-Infrared Biological Window for Second-Harmonic Generation by Amphiphilic Porphyrins
A1 Mey, Kurt De
A1 Perez-Moreno, Javier
A1 Reeve, James E.
A1 López Duarte, Ismael
A1 Boczarow, Igor
A1 Anderson, Harry L.
A1 Clays, Koen
AB We have applied the Thomas-Kuhn sum rules to model the wavelength dependence of the second-order nonlinear polarizability of an amphiphilic porphyrin chromophore designed for cellular imaging on the basis of the complete analysis of its linear absorption spectrum. We predict huge oscillations for this first hyperpolarizability in the biological transparency window with the second-order response exhibiting three minima and two maxima in the wavelength range between 700 and 900 nm and a second region of enhanced response between 1200 and 1500 nm. We confirmed the predicted values experimentally demonstrating both the validity of our approach and the need for a wavelength scan to find a maximum in the resonance-enhanced signal for cellular imaging. These results suggest a new approach toward achieving spectroscopic selectivity during second-harmonic generation imaging
PB American Chemical Society
SN 1932-7447
SN 1932-7455
YR 2012
FD 2012-06-19
LK https://hdl.handle.net/20.500.14352/114764
UL https://hdl.handle.net/20.500.14352/114764
LA eng
NO Mey KD, Perez-Moreno J, Reeve JE, Lopez-Duarte I, Boczarow I, Anderson HL, et al. Strong wavelength dependence of hyperpolarizability in the near-infrared biological window for second-harmonic generation by amphiphilic porphyrins. J Phys Chem C [Internet]. 28 de junio de 2012 [citado 16 de enero de 2025];116(25):13781-7. Disponible en: https://pubs.acs.org/doi/10.1021/jp302050j
NO EPSRC (EP/H018565/1)
NO FWO-V (G.0312.08)
NO European Commission-ERC
DS Docta Complutense
RD 4 abr 2025