RT Journal Article
T1 Prostanoid function and cardiovascular disease
A1 Iñiguez, Miguel A.
A1 Cacheiro Llaguno, Cristina
A1 Cuesta Rubio, Natalia
A1 Díaz Muñoz, Manuel D.
A1 Fresno, Manuel
AB Prostanoids, including prostaglandins (PGs) and thromboxanes (TXs) are synthesized from arachidonic acid by the combined action of cyclooxygenases (COXs) and PG and TX synthases. Finally after their synthesis, prostanoids are quickly released to the extracellular medium exerting their effects upon interaction with prostanoid receptors present in the neighbouring cells. These agents exert important actions in the cardiovascular system, modulating vascular homeostasis and participating in the pathogenesis of vascular diseases as thrombosis and atherosclerosis. Among prostanoids, Tromboxane (TX)A(2), a potent platelet activator and vasoconstrictor and prostacyclin (PGI2), a platelet inhibitor and vasodilator, are the most important in controlling vascular homeostasis. Although multiple studies using pharmacological inhibitors and genetically deficient mice have demonstrated the importance of prostanoid-mediated actions on cardiovascular physiology, further analysis on the prostanoid mediated actions in the vascular system are required to better understand the benefits and risks for the use of COX inhibitors in cardiovascular diseases.
PB Taylor and Francis
SN 1381-3455
YR 2008
FD 2008-10-10
LK https://hdl.handle.net/20.500.14352/116011
UL https://hdl.handle.net/20.500.14352/116011
LA eng
NO Iñiguez MA, Cacheiro-Llaguno C, Cuesta N, Díaz-Muñoz MD, Fresno M. Prostanoid function and cardiovascular disease. Arch Physiol Biochem. 2008 Jul;114(3):201-9. doi: 10.1080/13813450802180882.
DS Docta Complutense
RD 6 abr 2025