RT Journal Article T1 Latent Factors Limiting the Performance of sEMG-Interfaces A1 Lobov, Sergey A1 Krilova, Nadia A1 Kastalskiy, Innokentiy A1 Kazantsev, Victor A1 Makarov Slizneva, Valeriy AB Recent advances in recording and real-time analysis of surface electromyographic signals (sEMG) have fostered the use of sEMG human–machine interfaces for controlling personal computers, prostheses of upper limbs, and exoskeletons among others. Despite a relatively high mean performance, sEMG-interfaces still exhibit strong variance in the fidelity of gesture recognition among different users. Here, we systematically study the latent factors determining the performance of sEMG-interfaces in synthetic tests and in an arcade game. We show that the degree of muscle cooperation and the amount of the body fatty tissue are the decisive factors in synthetic tests. Our data suggest that these factors can only be adjusted by long-term training, which promotes fine-tuning of low-level neural circuits driving the muscles. Short-term training has no effect on synthetic tests, but significantly increases the game scoring. This implies that it works at a higher decision-making level, not relevant for synthetic gestures. We propose a procedure that enables quantification of the gestures’ fidelity in a dynamic gaming environment. For each individual subject, the approach allows identifying “problematic” gestures that decrease gaming performance. This information can be used for optimizing the training strategy and for adapting the signal processing algorithms to individual users, which could be a way for a qualitative leap in the development of future sEMG-interfaces. PB MDPI SN 1424-8220 YR 2018 FD 2018-04-06 LK https://hdl.handle.net/20.500.14352/12436 UL https://hdl.handle.net/20.500.14352/12436 LA eng NO Ministerio de Economía y Competitividad (MINECO) NO Ministry of education and science (Russia) DS Docta Complutense RD 28 abr 2025