RT Journal Article
T1 Early functional network alterations in asymptomatic elders at risk for Alzheimer’s disease
A1 Cuesta Prieto, Pablo
A1 Nakamura, Akinori
A1 Kato, Takashi
A1 Arahata, Yutaka
A1 Iwata, Kaori
A1 Yamagishi, Misako
A1 Kuratsubo, Izumi
A1 Kato, Kimiko
A1 Bundo, Masahiko
A1 Diers, Kersten
A1 Maestu Unturbe, Fernando
A1 Fernández Lucas, Alberto Amable
A1 Ito, Kengo
AB Amyloid-β (Aβ) deposition is known to starts decades before the onset of clinical symptoms of Alzheimer’s disease (AD), however, the detailed pathophysiological processes underlying this preclinical period are not well understood. This study aimed to investigate functional network alterations in cognitively intact elderly individuals at risk for AD, and assessed the association between these network alterations and changes in Aβ deposition, glucose metabolism, and brain structure. Forty-five cognitively normal elderly subjects, who were classified into Aβ-positive (CN+) and Aβ-negative (CN−) groups using 11C-Pittsburgh compound B PET, underwent resting state magnetoencephalography measurements, 18F-fluorodeoxyglucose PET (FDG-PET) and structural MRI. Results demonstrated that in the CN+ group, functional connectivity (FC) within the precuneus was significantly decreased, whereas it was significantly enhanced between the precuneus and the bilateral inferior parietal lobules in the low-frequency bands (theta and delta). These changes were suggested to be associated with local cerebral Aβ deposition. Most of Aβ+ individuals in this study did not show any metabolic or anatomical changes, and there were no significant correlations between FC values and FDG-PET or MRI volumetry data. These results demonstrate that functional network alterations, which occur in association with Aβ deposition, are detectable using magnetoencephalography before metabolic and anatomical changes are seen.
PB Nature
YR 2017
FD 2017-06-20
LK https://hdl.handle.net/20.500.14352/100615
UL https://hdl.handle.net/20.500.14352/100615
LA eng
NO Nakamura, A., Cuesta, P., Kato, T. et al. Early functional network alterations in asymptomatic elders at risk for Alzheimer’s disease. Sci Rep 7, 6517 (2017).
DS Docta Complutense
RD 22 abr 2025