RT Journal Article
T1 Hypercytokinemia in COVID-19: Tear cytokine profile in hospitalized COVID-19 patients
A1 Burgos Blasco, Bárbara
A1 Güemes Villahoz, Noemi
A1 Santiago García, José Antonio
A1 Santiago, José Luis
A1 Fernández Vigo, José Ignacio
A1 Espino Paisán, Laura
A1 Sarriá Ruíz, Beatriz Irene
A1 García Feijoo, Julián
A1 Martínez de la Casa, Jose Maria
AB The aim of this study is to analyze the concentrations of cytokines in tear of hospitalized COVID-19 patients compared to healthy controls. Tear samples were obtained from 41 healthy controls and 62 COVID-19 patients. Twenty-seven cytokines were assessed: interleukin (IL)-1b, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12, IL-13, IL-15, IL-17, eotaxin, fibroblast growth factor basic, granulocyte colony-stimulating factor (G-CSF), granulocyte-monocyte colony-stimulating factor (GM-CSF), interferon (IFN)-γ, interferon gamma-induced protein, monocyte chemo-attractant protein-1, macrophage inflammatory protein (MIP)-1a, MIP-1b, platelet-derived growth factor (PDGF), regulated on activation normal T cell expressed and secreted, tumor necrosis factor-α and vascular endothelial growth factor (VEGF).
In tear samples of COVID-19 patients, an increase in IL-9, IL-15, G-CSF, GM-CSF, IFN-γ, PDGF and VEGF was observed, along with a decrease in eotaxin compared to the control group (p < 0.05). A poor correlation between IL-6 levels in tear and blood was found. IL-1RA and GM-CSF were significantly lower in severe patients and those who needed treatment targeting the immune system (p < 0.05). Tear cytokine levels corroborate the inflammatory nature of SARS-CoV-2.
PB Elsevier
SN 0014-4835
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/6672
UL https://hdl.handle.net/20.500.14352/6672
LA eng
NO Received 29 July 2020, Revised 30 August 2020, Accepted 14 September 2020, Available online 16 September 2020
DS Docta Complutense
RD 6 may 2024