RT Journal Article
T1 Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain
A1 Gómez Pinedo, Ulises
A1 Matias Guiu, Jordi A.
A1 Benito Martín, María Soledad
A1 Moreno Jiménez, Lidia
A1 Sanclemente Alamán, Inmaculada
A1 Selma Calvo, Belen
A1 Pérez Suárez:, Sara
A1 Sancho Bielsa, Francisco
A1 Canales Aguirre, Alejandro
A1 Mateos Díaz, Juan Carlos
A1 Hernández Sapiéns, Mercedes A.
A1 Reza Zaldívar, Edwin E.
A1 Ojeda Hernández, Doddy Denise
A1 Vidorreta Ballesteros, Lucía
A1 Montero Escribano, Paloma
A1 Matías-Guiu Guía, Jorge
AB Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over time. Several experimental studies have introduced OPCs to the brain via direct injection or intrathecal administration. In this study, we used the nose-to brain pathway to deliver oligodendrocyte lineage cells (human oligodendroglioma (HOG) cells), which behave similarly to OPCs in vitro. To this end, we administered GFP-labelled HOG cells intranasally to experimental animals, which were subsequently euthanised at 30 or 60 days. Our results show that the intranasal route is a viable route to the CNS and that HOG cells administered intranasally migrate preferentially to niches of OPCs (clusters created during embryonic development and adult life). Our study provides evidence, albeit limited, that HOG cells either form clusters or adhere to clusters of OPCs in the brains of experimental animals.
PB MPDI
SN 1422-0067
YR 2021
FD 2021-10-04
LK https://hdl.handle.net/20.500.14352/4838
UL https://hdl.handle.net/20.500.14352/4838
LA eng
NO Gómez Pinedo, U., Matias-Guiu, J. A., Benito Martín, M. S. et al. «Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain». International Journal of Molecular Sciences, vol. 22, n.o 19, octubre de 2021, p. 10738. DOI.org (Crossref), https://doi.org/10.3390/ijms221910738.
NO Instituto de Salud Carlos III (ISCIII)
DS Docta Complutense
RD 7 abr 2025