RT Journal Article
T1 Evolutionarily diverse origins of deformed wing viruses in western honey bees
A1 Hasegawa, Nonno
A1 Techer, Maeva A.
A1 Adjlane, Noureddine
A1 Al-Hissnawi, Muntasser Sabah
A1 Antúnez, Karina
A1 Beaurepaire, Alexis
A1 Christmon, Krisztina
A1 Delatte, Helene
A1 Dukku, Usman H.
A1 Eliash, Nurit
A1 El-Niweiri, Mogbel A. A.
A1 Esnault, Olivier
A1 Evans, Jay D.
A1 Haddad, Nizar J.
A1 Locke, Barbara
A1 Muñoz Gabaldón, Irene
A1 Noël, Grégoire
A1 Panziera, Delphine
A1 Roberts, John M. K.
A1 De la Rúa, Pilar
A1 Shebl, Mohamed A.
A1 Stanimirovic, Zoran
A1 Rasmussen, David A.
A1 Mikheyev, Alexander S.
AB Novel transmission routes can allow infectious diseases to spread, often with devastating consequences. Ectoparasitic varroa mites vector a diversity of RNA viruses, having switched hosts from the eastern to western honey bees (Apis cerana to Apis mellifera). They provide an opportunity to explore how novel transmission routes shape disease epidemiology. As the principal driver of the spread of deformed wing viruses (mainly DWV-A and DWV-B), varroa infestation has also driven global honey bee health declines. The more virulent DWV-B strain has been replacing the original DWV-A strain in many regions over the past two decades. Yet, how these viruses originated and spread remains poorly understood. Here, we use a phylogeographic analysis based on whole-genome data to reconstruct the origins and demography of DWV spread. We found that, rather than reemerging in western honey bees after varroa switched hosts, as suggested by previous work, DWV-A most likely originated in East Asia and spread in the mid-20th century. It also showed a massive population size expansion following the varroa host switch. By contrast, DWV-B was most likely acquired more recently from a source outside East Asia and appears absent from the original varroa host. These results highlight the dynamic nature of viral adaptation, whereby a vector’s host switch can give rise to competing and increasingly virulent disease pandemics. The evolutionary novelty and rapid global spread of these host–virus interactions, together with observed spillover into other species, illustrate how increasing globalization poses urgent threats to biodiversity and food security.
PB National Academy of Sciences of the United States of America
SN 0027-8424
YR 2023
FD 2023-06-20
LK https://hdl.handle.net/20.500.14352/126121
UL https://hdl.handle.net/20.500.14352/126121
LA eng
NO Hasegawa, N., Techer, M. A., Adjlane, N., Al-Hissnawi, M. S., Antúnez, K., Beaurepaire, A., Christmon, K., Delatte, H., Dukku, U. H., Eliash, N., El-Niweiri, M. A. A., Esnault, O., Evans, J. D., Haddad, N. J., Locke, B., Muñoz, I., Noël, G., Panziera, D., Roberts, J. M. K., et al. (2023). Evolutionarily diverse origins of deformed wing viruses in western honey bees. Proceedings of the National Academy of Sciences of the United States of America, 120(26). https://doi.org/10.1073/PNAS.2301258120
NO A.S.M. recibió apoyo de una beca Future Fellowship del Consejo Australiano de Investigación (FT160100178) y una subvención Kakenhi para la Investigación Científica de la JSPS (Sociedad Japonesa para la Promoción de la Ciencia) (18H02216). La investigación de M.A.T. recibió apoyo de una beca postdoctoral de la JSPS (P19723) y una subvención Kakenhi (19F19723).
NO Australian Research Council
NO Japan Association for the Promotion of Science
DS Docta Complutense
RD 20 mar 2026