RT Journal Article
T1 Multivalent Tryptophan‐ and Tyrosine‐Containing [60]Fullerene Hexa‐Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors
A1 Ruiz Santaquiteria, Marta
A1 Illescas Martínez, Beatriz María
A1 Abdelnabi, Rana
A1 Boonen, Arnaud
A1 Mills, Alberto
A1 Martí‐Marí, Olaia
A1 Noppen, Sam
A1 Neyts, Johan
A1 Schols, Dominique
A1 Gago, Federico
A1 San‐Félix, Ana
A1 Camarasa, María‐José
A1 Martín, Nazario
AB Unprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity of these novel compounds against HIV and EV71 reveal that they are much more potent against HIV and equally active against EV71 than the previously described dendrimer prototypes AL-385 and AL-463, which possess the same number of Trp/Tyr residues on the periphery but attached to a smaller and more flexible pentaerythritol core. These results demonstrate the relevance of the globular 3D presentation of the peripheral groups (Trp/Tyr) as well as the length of the spacer connecting them to the central core to interact with the viral envelopes, particularly in the case of HIV, and support the hypothesis that [60]fullerene can be an alternative and attractive biocompatible carbon-based scaffold for this type of highly symmetrical dendrimers. In addition, the functionalized fullerenes here described, which display twelve peripheral negatively charged indole moieties on their globular surface, define a new and versatile class of compounds with a promising potential in biomedical applications.
PB Wiley
SN 0947-6539
YR 2021
FD 2021-04-14
LK https://hdl.handle.net/20.500.14352/6752
UL https://hdl.handle.net/20.500.14352/6752
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
NO Ministerio de Ciencia e Innovación (MICINN)
NO Consejo Superior de Investigaciones Científicas (CSIC)
NO “The Centers of Excellence” of the KU Leuven
DS Docta Complutense
RD 15 dic 2025