RT Journal Article T1 An Early, Universal Mediterranean Diet-Based Intervention in Pregnancy Reduces Cardiovascular Risk Factors in the “Fourth Trimester” A1 Assaf Balut, Carla A1 Garcia De La Torre, Nuria A1 Durán Rodríguez-Hervada, Alejandra A1 Bordiú, Elena A1 Valle, Laura Del A1 Familiar, Cristina A1 Valerio, Johanna A1 Jimenez, Inés A1 Herraiz Martínez, Miguel Ángel A1 Izquierdo Méndez, Nuria A1 Runkle De La Vega, Isabel Ana A1 De Miguel Novoa, María De La Paz A1 Montañez, Carmen A1 Barabash Bustelo, Ana A1 Cuesta, Martín A1 Rubio Herrera, Miguel Ángel A1 Calle Pascual, Alfonso Luis AB An early antenatal dietary intervention could play an important role in the prevention of metabolic diseases postpartum. The aim of this study is to evaluate whether an early, specific dietary intervention reduces women’s cardiovascular risk in the “fourth trimester”. This prospective cohort study compares 1675 women from the standard-care group (ScG/n = 676), who received standard-care dietary guidelines, with the intervention group (IG/n = 999), who received Mediterranean diet (MedDiet)-based dietary guidelines, supplemented with extra-virgin olive oil and nuts. Cardiovascular risk was determined by the presence of metabolic syndrome (MetS) and insulin resistance syndrome (IrS) (HOMA-IR 3.5) at 12–14 weeks postpartum. MetS was less frequent in the IG (11.3 vs. 19.3%, p < 0.05). The intervention was associated with a reduction in the relative risk of having MetS: 0.74 (95% CI, 0.60–0.90), but not in the risk of IrS. When analyzing the presence of having one or more components of the MetS, the IG had significantly higher rates of having 0 components and lower rates of having ≥1 (p-trend = 0.029). An early MedDiet-based nutritional intervention in pregnancy is associated with reductions in postpartum rates of MetS. PB MDPI SN 2077-0383 YR 2019 FD 2019-09-19 LK https://hdl.handle.net/20.500.14352/12574 UL https://hdl.handle.net/20.500.14352/12574 LA eng NO Assaf Balut, C., García De La Torre, N., Durán Rodríguez-Hervada, A. et al. «An Early, Universal Mediterranean Diet-Based Intervention in Pregnancy Reduces Cardiovascular Risk Factors in the “Fourth Trimester”». Journal of Clinical Medicine, vol. 8, n.o 9, septiembre de 2019, p. 1499. DOI.org (Crossref), https://doi.org/10.3390/jcm8091499. NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional DS Docta Complutense RD 26 abr 2025