RT Book, Section
T1 EPIPOX: A Resource Facilitating Epitope-Vaccine Design Against Human Pathogenic Orthopoxviruses
A1 Ballesteros Sanabria, Laura
A1 Peláez Prestel, Héctor Fernando
A1 Reche Gallardo, Pedro Antonio
A1 Lafuente Duarte, María Esther
A2 Pedro A. Reche, 
A2 Reche Gallardo, Pedro Antonio
AB EPIPOX is a specialized online resource intended to facilitate the design of epitope-based vaccines against orthopoxviruses. EPIPOX is built upon a collection of T cell epitopes that are shared by eight pathogenic orthopoxviruses, including variola minor and major strains, monkeypox, cowpox, and vaccinia viruses. In EPIPOX, users can select T cell epitopes attending to the predicted binding to distinct major histocompatibility molecules (MHC) and according to various features that may have an impact on epitope immunogenicity. Among others, EPIPOX allows to discern epitopes by their structural location in the virion and the temporal expression of the counterpart antigens. Overall, the annotations in EPIPOX are optimized to facilitate the rational design of T cell epitope-based vaccines. In this chapter, we describe the main features of EPIPOX and exemplify its use, retrieving orthopoxvirus-specific T cell epitopes with features set to enhance their immunogenicity. EPIPOX is available for free public use at http://bio.med.ucm.es/epipox/ .
PB Springer Nature Link
SN 9781071632383
SN 9781071632390
SN 1064-3745
SN 1940-6029
YR 2023
FD 2023-06-01
LK https://hdl.handle.net/20.500.14352/116120
UL https://hdl.handle.net/20.500.14352/116120
LA eng
NO Ballesteros-Sanabria L, Pelaez-Prestel HF, Reche PA, Lafuente EM. EPIPOX: A Resource Facilitating Epitope-Vaccine Design Against Human Pathogenic Orthopoxviruses. Methods Mol Biol. 2023;2673:175-185. doi:10.1007/978-1-0716-3239-0_12
NO Comunidad Autónoma de Madrid
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 9 abr 2025