RT Journal Article
T1 Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment
A1 Dammak, Azza
A1 Pastrana Robles, Cristina
A1 Martín Gil, Alba
A1 Carpena Torres, Carlos
A1 Peral Cerda, María Asunción
A1 Simovart, Mirjam
A1 Alarma-Estrany, Pilar
A1 Huete Toral, Fernando
A1 Carracedo Rodríguez, Juan Gonzalo
AB The eye is a metabolically active structure, constantly exposed to solar radiations making its structure vulnerable to the high burden of reactive oxygen species (ROS), presenting many molecular interactions. The biomolecular cascade modification is caused especially in diseases of the ocular surface, cornea, conjunctiva, uvea, and lens. In fact, the injury in the anterior segment of the eye takes its origin from the perturbation of the pro-oxidant/antioxidant balance and leads to increased oxidative damage, especially when the first line of antioxidant defence weakens with age. Furthermore, oxidative stress is related to mitochondrial dysfunction, DNA damage, lipid peroxidation, protein modification, apoptosis, and inflammation, which are involved in anterior ocular disease progression such as dry eye, keratoconus, uveitis, and cataract. The different pathologies are interconnected through various mechanisms such as inflammation, oxidative stress making the diagnostics more relevant in early stages. The end point of the molecular pathway is the release of different antioxidant biomarkers offering the potential of predictive diagnostics of the pathology. In this review, we have analysed the oxidative stress and inflammatory processes in the front of the eye to provide a better understanding of the pathomechanism, the importance of biomarkers for the diagnosis of eye diseases, and the recent treatment of anterior ocular diseases.
PB MDPI
SN 2227-9059
YR 2023
FD 2023-01-20
LK https://hdl.handle.net/20.500.14352/73122
UL https://hdl.handle.net/20.500.14352/73122
LA eng
NO Dammak, A., Pastrana Robles, C., Martín Gil, A. et al. «Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment». Biomedicines, vol. 11, n.o 2, enero de 2023, p. 292. DOI.org (Crossref), https://doi.org/10.3390/biomedicines11020292.
NO Unión Europea
DS Docta Complutense
RD 25 ago 2024