RT Journal Article
T1 Longitudinal analysis of corpus callosum diffusion tensor imaging metrics and its association with neurological outcome
A1 Castaño León, Ana
A1 Cicuendez, Marta
A1 Navarro, Blanca
A1 Paredes Sansinenea, Igor
A1 Munarriz, Pablo
A1 Cepeda, Santiago
A1 Hilario Barrio, Amaya
A1 Ramos González, Ana
A1 Gómez López, Pedro Antonio
A1 Lagares Gómez-Abascal, Alfonso
AB Traumatic axonal injury (TAI) is the main cause of cognitive and psychological disfunction after a traumatic brain injury (TBI). Diffusion tensor imaging (DTI) is considered a useful technique for indirect assessment of white matter (WM) integrity after a TBI. Scattered WM alterations and its relationship with patient severity have been discovered in normal appearing conventional magnetic resonance imaging (MRI) studies based on DTI sequences. However, there is a lack of large sample studies on the longitudinal changes of DTI metrics to be used to determine the temporal profile after head injury and its association with patient outcome. We performed a prospective observational study in 118 moderate-To-severe TBI patients. The study included clinical outcome assessment based on the Glasgow Outcome Scale Extended (GOSE) and serial DTI studies in the early subacute setting (< 60 days) and 6 and 12 months after injury. Fractional anisotropy (FA) and axial and radial diffusivities (AD and RD, respectively) were measured in the three portions of corpus callosum (genu, body, splenium) at each time-point and compared with normalized values from an age-matched control group. Longitudinal FA analysis and its correlation with patient improvement also was done by non-parametric testing and ordinal regression analysis. Our main results indicated that between all the time-points, dynamic changes in DTI metrics in all three portions of corpus callosum were detected, but TBI patients continued to show significantly lower FA and AD values and higher RD values compared with controls. We also have discovered differences in the change of DTI metrics among different time-points in patient subgroups according with their outcome improvement. In conclusion, even without normalization of DTI metrics in the long-Term, knowledge of the temporal profile of change in DTI metrics can provide important information about patients' clinical recovery after TBI.
PB Mary Ann Liebert
SN 0897-7151
YR 2019
FD 2019-09-10
LK https://hdl.handle.net/20.500.14352/116245
UL https://hdl.handle.net/20.500.14352/116245
LA eng
NO Castaño-Leon AM, Cicuendez M, Navarro B, Paredes I, Munarriz PM, Cepeda S, Hilario A, Ramos A, Gomez PA, Lagares A. Longitudinal Analysis of Corpus Callosum Diffusion Tensor Imaging Metrics and Its Association with Neurological Outcome. J Neurotrauma. 2019 Oct 1;36(19):2785-2802.
NO Instituto de Salud Carlos III
NO Unión Europea
DS Docta Complutense
RD 12 abr 2025