%0 Journal Article
%A Lorenzo Aparicio, María Del Carmen
%A García Álvarez, Pablo
%A Cabeza de Marco, Javier
%A Gómez Gallego, María Del Mar
%A Sierra Rodríguez, Miguel Ángel
%T Nucleobase stacking sustained by pt pt interactions
%D 2024
%U https://hdl.handle.net/20.500.14352/109969
%X This article reports the use of metal–metal interactions as a way to induce nucleobase stacking in a dinucleotide chain. We synthetized and study a series of C,N-cyclometallated platinum(II) binuclear complexes derived from 6-phenylpurine dinucleotide 1 as proligand, and β-diketonates, 2,2'-bipyridines and 1,10-phenanthroline as ancillary ligands. The X-ray diffraction analysis revealed that the diketonate derivatives 7 and 8 are chiral helixes sustained by Pt−Pt intramolecular interactions that allow the nucleobase stacking. The folded helical structures are maintained in solution, as demonstrated by the appearance of metal–metal-to-ligand charge-transfer (MMLCT) transitions in the UV-vis spectra. The influence of the ancillary ligand in the molecular structure was evidenced by the absence of bands derived from M−M interactions in the absorption spectra of 2,2’-bipyridine and and 1,10-phenanthroline derivatives 12–14. The existence of Pt−Pt in the complexes of this study can be also detected by electrochemistry.
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