RT Journal Article
T1 Nucleobase stacking sustained by pt pt interactions
T2 Apilamiento de Nucleobases mediado por interacciones Pt-Pt
A1 Lorenzo Aparicio, María Del Carmen
A1 García Álvarez, Pablo
A1 Cabeza de Marco, Javier
A1 Gómez Gallego, María Del Mar
A1 Sierra Rodríguez, Miguel Ángel
A2 De Cola, Luisa
AB This article reports the use of metal–metal interactions as a way to induce nucleobase stacking in a dinucleotide chain. We synthetized and study a series of C,N-cyclometallated platinum(II) binuclear complexes derived from 6-phenylpurine dinucleotide 1 as proligand, and β-diketonates, 2,2'-bipyridines and 1,10-phenanthroline as ancillary ligands. The X-ray diffraction analysis revealed that the diketonate derivatives 7 and 8 are chiral helixes sustained by Pt−Pt intramolecular interactions that allow the nucleobase stacking. The folded helical structures are maintained in solution, as demonstrated by the appearance of metal–metal-to-ligand charge-transfer (MMLCT) transitions in the UV-vis spectra. The influence of the ancillary ligand in the molecular structure was evidenced by the absence of bands derived from M−M interactions in the absorption spectra of 2,2’-bipyridine and and 1,10-phenanthroline derivatives 12–14. The existence of Pt−Pt in the complexes of this study can be also detected by electrochemistry.
PB Wiley
YR 2024
FD 2024-02-02
LK https://hdl.handle.net/20.500.14352/109969
UL https://hdl.handle.net/20.500.14352/109969
LA eng
NO Lorenzo-Aparicio, C.; García-Álvarez, P.; Cabeza, J. A.; Gómez-Gallego, M. ; Sierra, M. A. ChemistryEurope 2024, e202300065
NO Supporting information
NO MCIN
DS Docta Complutense
RD 13 abr 2025