RT Journal Article
T1 The global distribution and environmental drivers of the soil antibiotic resistome
A1 Delgado-Baquerizo, Manuel
A1 Hu, Hang-Wei
A1 Maestre, Fernando T.
A1 Guerra, Carlos A.
A1 Eisenhauer, Nico
A1 Eldridge, David J.
A1 Zhu, Yong-Guan
A1 Chen, Qing-Lin
A1 Trivedi, Pankaj
A1 Du, Shuai
A1 Makhalanyane, Thulani P.
A1 Verma, Jay Prakash
A1 Gozalo, Beatriz
A1 Ochoa, Victoria
A1 Asensio, Sergio
A1 Wang, Ling
A1 Zaady, Eli
A1 Illán, Javier G.
A1 Siebe, Christina
A1 Grebenc, Tine
A1 Zhou, Xiaobing
A1 Liu, Yu-Rong
A1 Bamigboye, Adebola R.
A1 Blanco-Pastor, José L.
A1 Duran, Jorge
A1 Rodríguez, Alexandra
A1 Mamet, Steven
A1 Alfaro, Fernando
A1 Abades, Sebastian
A1 López Teixido, Alberto
A1 Peñaloza-Bojacá, Gabriel F.
A1 Molina-Montenegro, Marco A.
A1 Torres-Díaz, Cristian
A1 Pérez, Cecilia
A1 Gallardo, Antonio
A1 García-Velázquez, Laura
A1 Hayes, Patrick E.
A1 Neuhauser, Sigrid
A1 He, Ji-Zheng
AB BackgroundLittle is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs.ResultsWe show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs.ConclusionsTogether, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.
PB BMC
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/94542
UL https://hdl.handle.net/20.500.14352/94542
LA eng
NO FundingThis project received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement 702057 (CLIMIFUN), a Large Research Grant from the British Ecological Society (agreement no. LRA17\1193; MUSGONET), and from the European Research Council (ERC grant agreement no. 647038, BIODESERT). M. D. B. was also supported by a Ramón y Cajal grant (RYC2018-025483-I). M.D-B. also acknowledges support from the Spanish Ministry of Science and Innovation for the I+D+i project PID2020-115813RA-I00 funded by MCIN/AEI/10.13039/501100011033. M.D-B. is also supported by a project of the Fondo Europeo de Desarrollo Regional (FEDER) and the Consejería de Transformación Económica, Industria, Conocimiento y Universidades of the Junta de Andalucía (FEDER Andalucía 2014-2020 Objetivo temático “01 - Refuerzo de la investigación, el desarrollo tecnológico y la innovación”) associated with the research project P20_00879 (ANDABIOMA). FTM acknowledges support from Generalitat Valenciana (CIDEGENT/2018/041). J. Z. H and H. W. H. are financially supported by Australian Research Council (DP210100332). We also thank the project CTM2015-64728-C2-2-R from the Ministry of Science of Spain. C. A. G. and N. E. acknowledge funding by the German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, funded by the German Research Foundation (FZT 118). TG was financially supported by Slovenian Research Agency (P4-0107, J4-3098 and J4-4547).
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 24 ago 2024